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Indiana vs. Ohio State: NCAA betting odds, preview, and pick

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February 21st, 2022

Two Big Ten rivals will meet for the second time on Monday evening, as the Ohio State Buckeyes look to avenge their previous loss to the Indiana Hoosiers.

Ohio State is 16-7 overall and 9-5 in Big Ten play, which is currently fourth in the conference. The Hoosiers, meanwhile, are 16-9 overall and 7-8 in conference play. Indiana is quickly finding themselves on the bubble for the NCAA Tournament, and this is a big game for their chances.

Let’s dive into this matchup, beginning with the latest betting odds available.

Tue, February 22 2022, 12:00 AM

Ohio State






O 135







U 135

Hoosiers are free-falling

Indiana enters this contest on a four-game losing streak. After starting the season at 16-5, including wins over Notre Dame and Purdue, Indiana now finds itself needing some impressive wins to stay in the field of 68 come Selection Sunday.

During their four-game losing streak, the Hoosiers had a bad loss to lowly Northwestern. Add on two more bad losses to Syracuse and Penn State, and this team is desperate to get some wins against good teams on the road. They have a terrible road record of 2-6 this season, with both wins against bottom-of-the-barrel Big Ten teams.

The good news for Indiana is that they defeated these Ohio State Buckeyes by 16 in their previous meeting in early January. It was an ugly, low-scoring game, but Trayce Jackson-Davis was able to find his scoring touch for 27 points and dominated on the boards, with 12 rebounds. He will need a repeat performance in this one.

Indiana and Ohio State Betting Trends

  • The home team is 5-0 ATS in the last five meetings
  • The Hoosiers are 0-9 ATS in their last nine games as a road underdog
  • The Buckeyes are 5-0 ATS in their last five Monday games
  • The Buckeyes are 5-1 ATS in their last six games following a straight-up loss
  • The Under is 6-1 in the Buckeyes' last seven games following an ATS loss

Buckeyes will defend their home court

Ohio State is an impressive 11-1 at home this year, with its one loss coming just this past weekend against Iowa. This includes wins over top national contenders Duke and Wisconsin.

The Buckeyes have yet to lose consecutive games this season, and they have a tough game at Illinois coming this Thursday.

They are in a strange situation where they have four games scheduled in only eight days due to postponements from earlier in the season.

This will be the second of the four games, which could be a good warmup for tournament play, where you must make quick turnarounds from game to game.

This meeting is a clash of two styles, as the Buckeyes are one of the better shooting teams in the nation, with a 47.9% field-goal percentage on the season. Meanwhile, the Hoosiers are one of the top defensive teams in the country, only allowing opponents to shoot 37.9% from the field.

Indiana’s style won out in the first meeting, as Ohio State shot only 30.8% from the field. However, I expect the Buckeyes to learn from their previous game and return home to shoot a much better percentage.

Ohio State is shooting 50.3% at home this year. Give me the Buckeyes to avoid losing consecutive games and to avenge their blowout loss with a blowout win.

Score prediction: Ohio State 71, Indiana 59

NCAAB pick: Ohio State -6

Indiana vs. Ohio State Pick powered by The Quant Edge

Our predictive engine is calling for the Buckeyes to win outright and cover the spread.