Cowboys vs. Patriots: NFL Week 6 betting odds, preview, and pick

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October 13th, 2021

An intriguing interconference matchup awaits NFL fans and bettors on Sunday afternoon as the Dallas Cowboys visit the New England Patriots.

The Cowboys are looking for their fifth straight win and fourth by double-digits in this one, while the Patriots would like to avoid their third straight nail-biter after having each of their last two games decided by three points or less (1-1 record). Let’s dive into the matchup to determine our best bet!

Dallas Cowboys (4-1) at New England Patriots (2-3), 4:25 p.m. ET, CBS

Sun, October 17 2021, 8:25 PM

NE Patriots






O 51.5

DAL Cowboys






U 51.5

The Cowboys can’t stop scoring

Dallas is currently the second-highest scoring team in the NFL, averaging 34 points per game. Only the Buffalo Bills (34.4) can boast a better scoring offense through five weeks.

Cowboys quarterback Dak Prescott is in fine form, completing 73.9% of his passes for 8.3 yards per attempt with 13 touchdowns and only three interceptions. He’s done a great job of spreading the ball around, as wide-out Amari Cooper leads the team in receiving touchdowns (four), wide-out CeeDee Lamb leads in receiving yards (348), and tight end Dalton Schultz leads in receptions (26).

Dallas is also getting incredible contributions on the ground from a resurgent Ezekiel Elliott (452 yards, third among all running backs) and Tony Pollard (325 yards). Only the Cleveland Browns are averaging more rushing yards per game than “America’s Team” through five weeks (187.6 to 172.8).

Mac Jones must be careful with the football

The Patriots are a modest 26th by points per game in 2021 (19.2), and rookie signal caller Mac Jones had had a lot to do with that. He’s clearly going through some growing pains based on his 5-5 touchdown-interception ratio through five weeks.

Unfortunately for Jones, the Cowboys lead the NFL in passes picked off with 10. That’s thanks mainly to cornerback Trevon Diggs, who has at least one interception in all five games he’s played in this year (six total).

Cowboys vs. Patriots injury report

Dallas CowboysNew England Patriots
Ezekiel Elliott: Questionable (ribs)
Damien Harris: Questionable (ribs)
Tyron Smith: Questionable (neck)
Shaq Mason: Questionable (abdomen)
Randy Gregory: Questionable (knee)
Isaiah Wynn: Questionable (COVID list)
Trevon Diggs: Questionable (ankle)
Michael Onwenu: Questionable (COVID list)

Cowboys and Patriots betting trends

  • The Cowboys are 5-0 ATS in their last five games overall
  • The Patriots are 10-2 ATS in their last 12 games as a home underdog
  • The Patriots are 2-10-1 ATS in their last 13 games following a straight-up win
  • The Over is 12-5 in the Cowboys’ last 17 games played in October
  • The Under is 8-1 in the Patriots’ last nine home games.

The verdict

The Patriots simply don’t have the firepower to keep up with the Cowboys in this one. Lay the points with Dallas on the road.

Score prediction: Cowboys 30, Patriots 17

NFL pick: Cowboys -4.5